E-Scripture: The Impact of Technology on the Reading of Sacred Texts (2013)

The tradition of religious readers in transition is not new: Augustine expressed “amazement” that Ambrose read silently and not aloud, movable type in the fifteenth century made the Bible publishable without scribal work, and today, electronic pages have become interactive in ways scarcely imagined a short time ago. How readers of today imagine a page (now conceptualized as a ‘web-page’) and consequently, reading in general, has profound implications for the 21st century. Acknowledging the fact that “the significance of a religious book lies not only in the message of its content, but also in the form and self-presentation with which it makes itself available to worship and transmission,” this project assumes that a great deal of perspective is provided by looking at this current transition in light of the old. In virtually all previous reading transitions, a religious ‘pattern of reading technology’ can be seen, whose pieces are all well-known but have not been collectively applied to the current situation of e-reading. The pattern operates with a three part assumption: readers will initially use a new technology to perform the same functions as the old technology, only more quickly, with more efficiency, or in greater quantity. This early use of new reading technology, in other words, largely attempts to imitate the functions and appearance of the old format. The second part is that the old technology becomes sacralized or ritualized in the face of the new technology’s standardization. As this standardization occurs, the new technology develops its own unique and innovative functions, exclusive to that form and shedding some or most of the imitative appearance and functions of the old technology – the third part of the pattern. Reviewing these transitions of the past and present, it becomes clear that perhaps fear of the new technology – however relatable – proves somewhat unfounded. New reading technology does not prove ultimately inimical to the old formats, or to religion, and despite many initial practical concerns, actually provides a multitude of benefits in the reading of sacred texts

THE GLOBAL REFLEX: DAVID M. STOWE AND AMERICAN ECUMENICAL MISSION IN A POSTCOLONIAL WORLD

With implications for historians of American culture and politics, human rights, Christianity, and transnationalism, this dissertation examines the role of global influences – especially “Third World” voices, theologies, movements, and postcolonial discourses – on American Protestant missionaries in the late twentieth century. To expose these influences, this dissertation examines the missiological and theological work of Protestant missionary, humanitarian, and mission executive David M. Stowe (1919-2000). Stowe’s experience makes clear the ways in which international experiences and dialogues placed missionaries in a unique position to serve as conduits for global influences to circulate back into American theology, humanitarian concern, and human rights advocacy. In particular, Stowe’s decades-long career provides a window into the Protestant rearticulation of “mission” to include humanitarian causes and human rights advocacy in the late 20th century, as manifested in the theological language he and his cohort used to describe and defend human rights as well as in their activism for justicerelated causes both in America and abroad. I hope to demonstrate that human rights conventions were given significant impetus and support from the concern for socio-economic justice, ecology, and other “Third World” issues shown by American religionists like Stowe. And rather than relegate this historical (and ongoing) engagement with human rights concepts by religious actors to a privatized sphere, I argue that contemporary human rights discourse would benefit from a better understanding of the effects of missionary experience on the historical development of humanitarianism. Beyond discursive value, moreover, the implementation of humanitarian and human rights concepts would also enjoy practical benefits from a familiarity with American Protestantism’s struggle to address twentieth-century anti-colonial critiques. In demonstrating these benefits by drawing connections between missionary experience and the emergence of American humanitarianism and human rights discourse, this research is ultimately aimed at bridging gaps between national and global, the West and the “rest,” and religious and secular histories

Genotypic Diversity and Host-Specificity of Frankia Bacteria Associated with Sympatric Populations of Alnus rubra and Alnus rhombifolia in Oregon

Biological nitrogen fixation is one of the most critical processes contributing to ecosystem productivity and stability on a global scale. In temperate climates of the northern hemisphere, plant-root associated bacteria of the genus Frankia are the major nitrogen fixers in forest environments. Trees belonging to the genus Alnus are the most widespread hosts of Frankia in the Pacific Northwest, and a myriad of biotic and abiotic factors can influence the robustness of this symbiosis. Host identity and bacterial strain are important features that can impact Alnus-Frankia association, but little is known about the interplay of intrageneric hosts that co-occur in natural settings. In this study we investigated the genetic diversity and host specificity of Frankia bacteria associated with sympatrically occurring populations of Alnus rubra (red alder) and Alnus rhombifolia (white alder) in Oregon. Based on sequence analysis of the nifH gene recovered from root nodules we found low overall bacterial diversity. One dominant Frankia genotype was associated with both host species, indicating a lack of strong host specificity in this system. Our results suggest that certain intrageneric plant hosts with overlapping distributions show cross-compatibility with symbiotic actinorhizal bacteria, and that low strain diversity of these bacteria can persist across mixed host populations

Seasonal evolution of supraglacial lakes on an East Antarctic outlet glacier

Supraglacial lakes are known to influence ice melt and ice flow on the Greenland ice sheet and potentially cause ice shelf disintegration on the Antarctic Peninsula. In East Antarctica, however, our understanding of their behavior and impact is more limited. Using >150 optical satellite images and meteorological records from 2000 to 2013, we provide the first multiyear analysis of lake evolution on Langhovde Glacier, Dronning Maud Land (69°11′S, 39°32′E). We mapped 7990 lakes and 855 surface channels up to 18.1 km inland (~670 m above sea level) from the grounding line and document three pathways of lake demise: (i) refreezing, (ii) drainage to the englacial/subglacial environment (on the floating ice), and (iii) overflow into surface channels (on both the floating and grounded ice). The parallels between these mechanisms, and those observed on Greenland and the Antarctic Peninsula, suggest that lakes may similarly affect rates and patterns of ice melt, ice flow, and ice shelf disintegration in East Antarctica

MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing

In the pursuit of improved diagnostic tests for infectious diseases, several classes of molecules have been scrutinized as prospective biomarkers. Small (18–22 nucleotide), non-coding RNA transcripts called microRNAs (miRNAs) have emerged as promising candidates with extensive diagnostic potential, due to their role in numerous diseases, previously established methods for quantitation and their stability within biofluids. Despite efforts to identify, characterize and apply miRNA signatures as diagnostic markers in a range of non-infectious diseases, their application in infectious disease has advanced relatively slowly. Here, we outline the benefits that miRNA biomarkers offer to the diagnosis, management, and treatment of infectious diseases. Investigation of these novel biomarkers could advance the use of personalized medicine in infectious disease treatment, which raises important considerations for validating their use as diagnostic or prognostic markers. Finally, we discuss new and emerging miRNA detection platforms, with a focus on rapid, point-of-care testing, to evaluate the benefits and obstacles of miRNA biomarkers for infectious disease

Stylasterid corals: a new paleotemperature archive

Stylasterids are a ubiquitous deep-sea coral taxon that build their skeletons from either calcite, aragonite, or both. Yet, robust geochemical proxy data from these corals are limited. In this study, 95 modern stylasterids, spanning a wide range of depths (63 to 2894 m) and ambient seawater temperatures (0 to 17 °C), were tested for their potential use as paleoceanographic archives. Stable oxygen and carbon isotopic composition (O and C) were measured from the main trunk of all specimens and five specimens were further sub-sampled to assess internal chemical variability. The isotope data show non-equilibrium precipitation from seawater for both O and C, with the growing tips of colonies yielding the isotopically lowest values. Overall, the calcitic corals showed lower isotope values for O and C than aragonitic specimens. Within the aragonite corals, we present a O:temperature calibration that exhibits a significant linear relationship with the equation Ocoral-seawater = −0.22(°C) + 3.33(±0.06) across a temperature range of 0 to 30 °C, using samples from this study and published data. This work highlights the potential application of stylasterid coral O data to reconstruct paleo seawater temperature

Microdamage generation by tapered and cylindrical mini-screw implants after pilot drilling

Objective:  To investigate the relationship between mini-screw implant (MSI) diameter (1.6 vs 2.0 mm) and shape (tapered vs cylindrical) and the amount of microdamage generated during insertion. Materials and Methods:  Thirty-six cylindrical and 36 tapered MSIs, 6 mm long, were used in this study. Half of each shape was 1.6 mm in diameter, while the other half was 2.0 mm. After pilot drilling, four and five MSIs were inserted, respectively, into fresh cadaveric maxillae and mandibles of dogs. Bone blocks containing the MSIs were sectioned and ground parallel to the MSI axis. Epifluorescent microscopy was used to measure overall cortical thickness, crack length, and crack number adjacent to the MSI. Crack density and total microdamage burden per surface length were calculated. Three-way analysis of variance (ANOVA) was used to test the effects of jaw, and MSI shape and diameter. Pairwise comparisons were made to control the overall significance level at 5%. Results:  The larger (2.0 vs 1.6 mm) cylindrical MSIs increased the numbers, lengths, and densities of microcracks, and the total microdamage burden. The same diameter cylindrical and tapered MSIs generated a similar number of cracks and crack lengths. More total microdamage burden was created by the 2.0-mm cylindrical than the 2.0-mm tapered MSIs. Although higher crack densities were produced by the insertion of 1.6-mm tapered MSIs, there was no difference in total microdamage burden induced by 1.6-mm tapered and 1.6-mm cylindrical MSIs. Conclusions:  Pilot drilling is effective in reducing microdamage during insertion of tapered MSIs. To prevent excessive microdamage, large diameter and cylindrical MSIs should be avoided

Age, sex, and socioeconomic differences in multimorbidity measured in four ways:UK primary care cross-sectional analysis

Background: Multimorbidity poses major challenges to healthcare systems worldwide. Definitions with cut-offs in excess of ≥2 long-term conditions (LTCs) might better capture populations with complexity but are not standardised. Aim: To examine variation in prevalence using different definitions of multimorbidity. Design and setting: Cross-sectional study of 1 168 620 people in England. Method: Comparison of multimorbidity (MM) prevalence using four definitions: MM2+ (≥2 LTCs), MM3+ (≥3 LTCs), MM3+ from 3+ (≥3 LTCs from ≥3 International Classification of Diseases, 10th revision chapters), and mental–physical MM (≥2 LTCs where ≥1 mental health LTC and ≥1 physical health LTC are recorded). Logistic regression was used to examine patient characteristics associated with multimorbidity under all four definitions. Results: MM2+ was most common (40.4%) followed by MM3+ (27.5%), MM3+ from 3+ (22.6%), and mental–physical MM (18.9%). MM2+, MM3+, and MM3+ from 3+ were strongly associated with oldest age (adjusted odds ratio [aOR] 58.09, 95% confidence interval [CI] = 56.13 to 60.14; aOR 77.69, 95% CI = 75.33 to 80.12; and aOR 102.06, 95% CI = 98.61 to 105.65; respectively), but mental–physical MM was much less strongly associated (aOR 4.32, 95% CI = 4.21 to 4.43). People in the most deprived decile had equivalent rates of multimorbidity at a younger age than those in the least deprived decile. This was most marked in mental–physical MM at 40–45 years younger, followed by MM2+ at 15–20 years younger, and MM3+ and MM3+ from 3+ at 10–15 years younger. Females had higher prevalence of multimorbidity under all definitions, which was most marked for mental–physical MM. Conclusion: Estimated prevalence of multimorbidity depends on the definition used, and associations with age, sex, and socioeconomic position vary between definitions. Applicable multimorbidity research requires consistency of definitions across studies

Magnetic exchange, anisotropy and excitonic fluctuations in a [Ni^II₇] Anderson wheel

The solvothermal reaction of Ni(ClO4)2·6H2O with hmpH and picH in a basic MeOH solution affords [Ni7(hmp)7.55(pic)4.45](ClO4)2·6MeOH (1·6MeOH) directly upon cooling the mother liquor. The metallic skeleton of 1 describes a [NiII7] centred hexagon, commonly referred to as an Anderson wheel. Magnetic measurements reveal ferromagnetic exchange between the central Ni ion and the ring Ni ions, and antiferromagnetic exchange between neighbouring ring Ni ions. They also confirm the presence of easy-plane anisotropy for the central Ni ion, and easy-axis anisotropy for the ring Ni ions, in agreement with DFT calculations and neutron scattering. For the analysis of the latter we apply an excitonic formalism using a Green's function response theory.</p

The impact of varying the number and selection of conditions on estimated multimorbidity prevalence::a cross-sectional study using a large, primary care population dataset

Background: Multimorbidity prevalence rates vary considerably depending on the conditions considered in the morbidity count, but there is no standardised approach to the number or selection of conditions to include. Methods and findings: We conducted a cross-sectional study using English primary care data for 1,168,260 participants who were all people alive and permanently registered with 149 included general practices. Outcome measures of the study were prevalence estimates of multimorbidity (defined as ≥2 conditions) when varying the number and selection of conditions considered for 80 conditions. Included conditions featured in ≥1 of the 9 published lists of conditions examined in the study and/or phenotyping algorithms in the Health Data Research UK (HDR-UK) Phenotype Library. First, multimorbidity prevalence was calculated when considering the individually most common 2 conditions, 3 conditions, etc., up to 80 conditions. Second, prevalence was calculated using 9 condition-lists from published studies. Analyses were stratified by dependent variables age, socioeconomic position, and sex. Prevalence when only the 2 commonest conditions were considered was 4.6% (95% CI [4.6, 4.6] p &lt; 0.001), rising to 29.5% (95% CI [29.5, 29.6] p &lt; 0.001) considering the 10 commonest, 35.2% (95% CI [35.1, 35.3] p &lt; 0.001) considering the 20 commonest, and 40.5% (95% CI [40.4, 40.6] p &lt; 0.001) when considering all 80 conditions. The threshold number of conditions at which multimorbidity prevalence was &gt;99% of that measured when considering all 80 conditions was 52 for the whole population but was lower in older people (29 in &gt;80 years) and higher in younger people (71 in 0- to 9-year-olds). Nine published condition-lists were examined; these were either recommended for measuring multimorbidity, used in previous highly cited studies of multimorbidity prevalence, or widely applied measures of “comorbidity.” Multimorbidity prevalence using these lists varied from 11.1% to 36.4%. A limitation of the study is that conditions were not always replicated using the same ascertainment rules as previous studies to improve comparability across condition-lists, but this highlights further variability in prevalence estimates across studies. Conclusions: In this study, we observed that varying the number and selection of conditions results in very large differences in multimorbidity prevalence, and different numbers of conditions are needed to reach ceiling rates of multimorbidity prevalence in certain groups of people. These findings imply that there is a need for a standardised approach to defining multimorbidity, and to facilitate this, researchers can use existing condition-lists associated with highest multimorbidity prevalence